Fulham meet Watford at Craven Cottage in the Premier League. The Hornets will be looking to return to winning ways after suffering a first loss of the season to Man Utd last time out.
Chris Hughton's Brighton welcome Tottenham to the Amex Stadium in the Premier League. Mauricio Pochettino's side look to get back to winning ways after three defeats in a row.
Queens Park Rangers take on Norwich City at Loftus Road in the Sky Bet Championship. QPR hammered their visitors 4-1 when the sides met here last season.
London rivals meet in the Premier League as West Ham United take on Chelsea at the London Stadium. The Hammers were 1-0 winners when these sides met here last season.
Arsenal face Everton at the Emirates Stadium in the Premier League. Arsenal won both meetings between the sides last season.
Lyon go toe-to-toe with Marseille in Ligue 1 at the Groupama Stadium. Lyon have a fantastic record against their opponents having lost just once in their last 16 league meetings.